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G8877 Sigma-Aldrich

Guanosine 5′-triphosphate sodium salt hydrate

≥95% (HPLC), powder

Synonym: GTP

  • CAS Number 36051-31-7

  • Empirical Formula (Hill Notation) C10H16N5O14P3 · xNa+

  • Molecular Weight 523.18 (free acid basis)

  •  Beilstein/REAXYS Number 3585677

  •  EC Number 252-847-2

  •  MDL number MFCD00077781

  •  PubChem Substance ID 24895354

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Description

Application

Guanosine 5′-triphosphate sodium salt hydrate has been used:
• in the preparation of horseradish peroxidase (HRP)-modified platination reagents
• in whole cell, voltage-clamp recordings
• in in vitro inhibition of transglutaminase (tTG)

Packaging

1 g in poly bottle

10, 25, 100, 250 mg in poly bottle

Biochem/physiol Actions

GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

Prepared by enzymatic phosphorylation of 5′-GMP.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC
Keywords: Chromatography, High performance liquid chromatography

LC/MS Analysis of Nucleotides SeQuant ZIC-cHILIC – Effect of pH

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Nucleotides SeQuant ZIC-cHILIC – Effect of pH
Keywords: High performance liquid chromatography, Mass spectrometry

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC – Effect of Mobile Phase Buffer Concentration

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC – Effect of Mobile Phase Buffer Concentration
Keywords: High performance liquid chromatography, Mass spectrometry

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC
Keywords: Buffers, Building blocks, Chromatography, High performance liquid chromatography, Ion-exchange chromatography, Mass spectrometry, Reversed-phase chromatography, Separation

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

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Peer-Reviewed Papers
15

References

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