• USA Home
  • G9038 - Anti-Glutamate Receptor NMDAR2A (NR2A) antibody produced in rabbit

G9038 Sigma

Anti-Glutamate Receptor NMDAR2A (NR2A) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Neurotransmission, Antibodies to Glutamate Receptors,
species reactivity   human, rat, mouse
application(s)   microarray: suitable
  western blot: 1:3,000 using extract of rat brain synaptosomal fraction.
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 170 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... GRIN2A(2903)
mouse ... Grin2a(14811)
rat ... Grin2a(24409)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to the C-terminal region of rat NMDAR2A (amino acids 1449-1464). This sequence is identical in human and mouse NMDAR2A and similar to the NMDAR2B sequence (70% identity).

General description

N-methyl-D-aspartate (NMDA) receptors are made up of NMDAR1 (NR1) and NMDAR2A-NMDAR2D (NR2A-NR2D) subunits. The glutamate receptor, N-methyl D-aspartate 2A (GRIN2A) gene encodes the 2A subunit of the NMDA receptor. The NMDA receptors are made up of NR1 and at least one subunit of the NR2 class, forming a hetero-pentamer complex.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.


The antibody reacts with NMDAR2A and may recognize the NMDAR2B subunit (NR2B).


Anti-Glutamate Receptor NMDAR2A (NR2A) antibody produced in rabbit is suitable as a primary antibody for immunoblotting using whole-tissue lysates or crude synaptosomal fractions of hippocampal slices from mice. It is suitable for immunoblotting at a working dilution of 1:3000 using a synaptosomal fraction of rat brain. It is also suitable for microarray analysis.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunoprecipitation (1 paper)

Biochem/physiol Actions

The NMDA receptors are permeable to Ca2+, Na+ and K+ and contain modulatory sites for Mg2+ , Zn2+, glycine, protons, and polyamines. These receptors are regulated by tyrosine phosphorylation. It is required for long term potentiation (LTP), a mechanism that facilitates learning and memory.

Price and Availability

Antibody Explorer

Explore with Confidence
Safety & Documentation

Safety Information

Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
WGK Germany  3
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy


Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

Related Content

Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Inflammation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers


Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?