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G9415 Sigma-Aldrich

Anti-GFRα-2 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-GDNF receptor-β, Anti-GDNFR-β, Anti-NTNR-α, Anti-RETL2, Anti-TmR2, Anti-neurturin receptor-α

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies to Cytokines and Growth Factors,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   western blot: 1-2 μg/mL using human HeLa cell extract
species reactivity   mouse, human, rat
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   IgG fraction of antiserum
antibody product type   primary antibodies
UniProt accession no.   O00451
Gene Information   human ... GFRA2(2675)
mouse ... Gfra2(14586)
rat ... Gfra2(25136)

Description

General description

GDNF family receptor α (GFR α) is a glycosylphos phatidylinositol (GPI)-anchored protein that belongs to GDNFR family. GFR α expresses mainly in nervous system. It behaves as a co-receptor to activate Ret and can facilitates the GDNF, NTN, PSP, and ART signaling. GDNF binds preferentially to GFR α-1, NTN to GFR α -2, ART to GFR α -3, and PSP to GFR α-4. Rabbit anti-GFRα-2 antibody reacts specifically with mouse, rat or human GFR α 2.

Immunogen

synthetic peptide corresponding to amino acids 377-391 of human GFRα-2.

Application

Anti-GFR α-2 antibody can be used in western blotting (1-2 μg/mL) using human HeLa cell extract.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
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References

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