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  • G9665 - Anti-Glutamate Receptor 1A, Metabotropic (mGluR1A) antibody produced in rabbit

G9665 Sigma

Anti-Glutamate Receptor 1A, Metabotropic (mGluR1A) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Neurotransmission, Antibodies to Glutamate Receptors,
species reactivity   rat, mouse, feline
application(s)   immunohistochemistry (frozen sections): 1:500
  western blot: 1:1,000
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous glycerol solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   mouse ... Grm1(14816)
rat ... Grm1(24414)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to the sequence of amino acids 1116-1130 of rat metabotropic glutamate receptor 1A (mGluR1a).

General description

The metabotropic glutamate receptors consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Glutamate is the main excitatory neurotransmitter in the brain. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors, involved in the fast excitatory synaptic transmission. Glutamate also regulates ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins, called metabotropic glutamate receptors.

Physical form

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol


This antibody does not react with other splice variants or mGluR5.


Anti-Glutamate Receptor 1A, Metabotropic (mGluR1A) antibody produced in rabbit is suitable for use as a primary antibody at a working dilution of 1:1500 using extracts from mouse brain It is suitable for immunohistochemistry at a working dilution of 1:500 and for immunoblotting at a working dilution of 1:1000.

Biochem/physiol Actions

Glutamate Receptor 1 is a G-protein coupled receptor for glutamate. The role of the metabotropic receptors in pain and pathology is being studied for therapeutic potential. Glutamate receptors are important mediators of excitatory amino acid neurotransmission. The α isomer of this receptor is a disulfide-linked homodimer and its activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Mutations in this gene causes autosomal-recessive congenital cerebellar ataxia.

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RIDADR  NONH for all modes of transport
WGK Germany  2
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