Capto L

Cytiva, 17-5478-02, pack of 200 mL

  •  NACRES NA.56



Related Categories Antibodies, Antibody Purification and Characterization, Protein A, G and L Resins, Supplementary Products
shelf life   Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
packaging   pack of 200 mL
mfr. no.   Cytiva, 17-5478-02
matrix   rigid, highly cross-linked agarose
avg. part. size   85 μm (d₅₀v is the median particle size of the cumulative volume distribution)
working range   2 - 10 (pH interval where the medium can be operated without significant change in function.)
suitability   suitable for bioprocess medium
storage temp.   2-8°C


General description

Capto L is a BioProcess chromatography medium (resin) for the capture of antibodies and antibody fragments. It combines a rigid, high-flow agarose matrix with the immunoglobulin-binding recombinant protein, L ligand, which has a strong affinity to the variable region of antibody kappa light chains. Capto L is suitable for the capture of a wide range of antibody fragments such as Fabs, single-chain variable fragments (scFv), and domain antibodies (Dabs).


Purification of antibody fragments using affinity chromatography

Analysis Note

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Legal Information

Capto is a trademark of Cytiva

Safety & Documentation

Safety Information

NONH for all modes of transport


Certificate of Analysis (COA)

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Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Performing a Purification of Antibody Fragments with Capto™ L Products

Monoclonal antibodies are typically purified using a platform approach where capture by protein A affinity chromatography has become the industry standard. However, a corresponding solution for antibod...
Keywords: Affinity chromatography, Chromatography, Fermentation, PAGE, Reductions, Size-exclusion chromatography


Effective Polishing of Domain Antibodies (DAbs) Using Capto MMC ImpRes

Antibody fragments (e.g., Fab, scFv, and DAbs, Fig 4.57) are becoming an important class of protein-based products. The structure and smaller size give antibody fragments properties to suit a range o...
Keywords: Buffers, Chromatography, Purification

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