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GW21062 Sigma-Aldrich

Anti-CD221 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-IGFIR, Anti-Insulin-like growth factor 1 receptor

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Properties

Related Categories A to L, Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology,
conjugate   unconjugated
clone   polyclonal
biological source   chicken
application(s)   western blot: suitable
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
mfr. no.   Genway, 15-288-21062
NCBI accession no.   NP_000866.1
UniProt accession no.   O43467
Gene Information   human ... IGF1R(3480)

Description

Immunogen

Immunogen Sequence: GI # 4557665, sequence 214-318

Recombinant insulin-like growth factor 1 receptor

Application

Anti-CD221 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Biochem/physiol Actions

The insulin-like growth factor 1 (IGF-1) receptor is a protein on human cell surface. It activates mitotic division and inhibits apoptosis of cancer cells. IGF-1R may play an important role in tumor growth and metastasis through lymphatic pathway. It may act as a biomarker in non-small cell lung cancer (NSCLC) and may be useful in customized chemotherapy. IGF1R inhibitor may constitute an attractive modality for treating endometrial cancer. Mutations in the gene lead to abnormal functioning of IGF-I receptors. It has also been reported that mutated CD221 may retard intrauterine and subsequent growth in humans.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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