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GW21070 Sigma-Aldrich

Anti-CXCL9 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Small inducible cytokine B9

  •  NACRES NA.41

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Properties

Related Categories A to L, Alphabetical Index, Antibodies, CT-CZ, IgY Antibodies,
conjugate   unconjugated
clone   polyclonal
biological source   chicken
application(s)   western blot: suitable
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
mfr. no.   Genway, 15-288-21070
NCBI accession no.   NP_002407.1
UniProt accession no.   Q07325
Gene Information   human ... CXCL9(4283)

Description

General description

CXCL9 (chemokine (C-X-C motif) ligand 9) is a ligand for chemokine (C-X-C motif) receptor 3 (CXCR3), which is inducible by interferon-γ. It is expressed on CD4+ Th1 cells and CD8+ cytotoxic T cells. It is also secreted by neutrophils and macrophages. It acts as a chemoattractant for activated T-lymphocytes.

Immunogen

Immunogen Sequence: GI # 4505187, sequence 21-64

Recombinant small inducible cytokine B9

Application

Anti-CXCL9 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Biochem/physiol Actions

Chemokine (C-X-C motif) ligand 9 (CXCL9) is more abundantly expressed in tumors cells than in normal epithelium. CXCL9 is associated with tumor and aggressiveness of NPC (nasopharyngeal carcinoma) tumors and the serum level of this may be useful as a prognostic indicator. In NPC tumors, serum concentration is found to be significantly higher. CXCL9 can act as a potential therapeutic target for human CGGN (Cryoglobulinemic glomerulonephritis).

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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