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GW21114 Sigma-Aldrich

Anti-KIT antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-C-Kit, Anti-CD117, Anti-Mast/stem cell growth factor receptor

  •  NACRES NA.41

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Properties

Related Categories A to L, Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology,
conjugate   unconjugated
clone   polyclonal
biological source   chicken
application(s)   western blot: suitable
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
mfr. no.   Genway, 15-288-21114
NCBI accession no.   NP_000213.1
UniProt accession no.   P10721
Gene Information   human ... KIT(3815)

Description

General description

KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) is a tyrosine kinase receptor, the gene of which is localized to human chromosome 4q12. It is a transmembrane receptor, and is also called CD117. It is expressed by mast cells, hematopoietic progenitor cells, germ cells, melanocytes and interstitial cells of Cajal.

Immunogen

Immunogen Sequence: GI # 4557695, sequence 113-208

Recombinant V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Application

Anti-KIT antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Biochem/physiol Actions

Mutations in receptor tyrosine kinase KIT, plays an important role in the pathogenesis of systemic mastocytosis (SM) and gastrointestinal stromal tumors. KIT tyrosine kinase receptors are implicated in the control of cell growth and differentiation, stem through duplications. KIT and its ligand and the stem cell factor play a key role in normal hematopoiesis.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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