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GW21171 Sigma-Aldrich

Anti-IKBKB antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-IKKB, Anti-IkB kinase β, Anti-Inhibitor of nuclear factor kappa B kinase subunit β



Related Categories A to L, Alphabetical Index, Antibodies, Antibodies for Epigenetics and Nuclear Signaling, Antibodies to Transcription Factors,
conjugate   unconjugated
clone   polyclonal
biological source   chicken
application(s)   western blot: suitable
species reactivity   mouse, rat, human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
NCBI accession no.   AAC64675.1
UniProt accession no.   O14920
Gene Information   human ... IKBKB(3551)



Immunogen Sequence: GI # 3213217, sequence 310-376

Recombinant IkB kinase β subunit; IKK β


Anti-IKBKB antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Biochem/physiol Actions

IKK-β (inhibitor of nuclear factor κ-B kinase subunit β) is a protein encoded by the IKBKB gene in humans. It helps in mediating tumor necrosis-factor α (TNFα) induced invasion of human mesenchymal stem cell (hMSC) to sites of tissue injury. IKK-2 activity suppression leads to reduced expression of proteolytic enzymes and impaired invasive capacity. Its activation is central to NF-κB signaling. IKK-β phosphorylation by IκB kinase (IKK) triggers the degradation of IκB and migration of cytoplasmic κB to the nucleus, where it promotes the transcription of its target genes. It is activated by phosphorylation of its main subunit, IKKβ, at the activation loop sites.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy


Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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