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GW21185 Sigma-Aldrich

Anti-CDKN2A antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3

  •  NACRES NA.41

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Properties

Related Categories A to L, Alphabetical Index, Antibodies, Antibodies for Epigenetics and Nuclear Signaling, Antibodies to Transcription Factors,
conjugate   unconjugated
clone   polyclonal
biological source   chicken
application(s)   western blot: suitable
species reactivity   mouse, human, rat
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
mfr. no.   Genway, 15-288-21185
NCBI accession no.   NP_000068.1
UniProt accession no.   P42771
Gene Information   human ... CDKN2A(1029)

Description

Immunogen

Immunogen Sequence: GI # 4502749, sequence 1-51

Recombinant cyclin-dependent kinase inhibitor 2A isoform 1

Application

Anti-CDKN2A antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

p16 (also known as cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor 1) is a tumor suppressor protein encoded by the CDKN2A gene in humans and is mapped on chromosome 9p21. The p16 gene encodes a negative regulator of the cell cycle. It is an important factor in carcinogenesis and its expression is linked to oncogene-induced senescence. p16 upregulation may be associated with the induction of senescence and indicates a senescence barrier while its downregulation is found in malignant progression. Its inhibitor may act as a physiological suppressor of proliferation and cells that are unable to produce the inhibitor may be prone to neoplastic transformation.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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