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  • GW21224 - Anti-PCCA antibody produced in chicken

GW21224 Sigma-Aldrich

Anti-PCCA antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Propionyl-CoA carboxylase α chain, mitochondrial



Related Categories Alphabetical Index, Antibodies, IgY Antibodies, M to Z, PB-PC,
conjugate   unconjugated
clone   polyclonal
biological source   chicken
application(s)   western blot: suitable
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
mfr. no.   Genway, 15-288-21224
NCBI accession no.   NP_000273.1
UniProt accession no.   P05165
Gene Information   human ... PCCA(5095)



Immunogen Sequence: GI # 4557833, sequence 450-703

Recombinant propionyl-Coenzyme A carboxylase, α polypeptide


Anti-PCCA antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Propionyl-CoA carboxylase (PCC) is a biotin-dependent mitochondrial enzyme that helps in catalyzing the conversion of propionyl-CoA to D-methylmalonyl-CoA. It consists of two heterologous subunits, αPCC and βPCC and is encoded by the nuclear PCCA and PCCB genes, respectively. The PCCA protein (α subunit) is responsible for the formation of carboxybiotin upon hydrolysis of ATP and contains a C-terminal biotin-binding domain and a biotin carboxylase domain. PCC deficiency due to mutation in either of the PCCA and PCCB genes leads to a metabolic disorder, propionic academia (PA), a common form of organic aciduria.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Protocols & Articles


Antibody Basics

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Western Blot Protocol | Immunoblotting Protocol

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