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GW21339 Sigma-Aldrich

Anti-ITGA3 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-CD49c, Anti-Integrin α-3, Anti-VL3A

  •  NACRES NA.41

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Properties

Related Categories A to L, Alphabetical Index, Antibodies, IQ-IZ, IgY Antibodies,
conjugate   unconjugated
clone   polyclonal
biological source   chicken
application(s)   western blot: suitable
species reactivity   rat, human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
mfr. no.   Genway, 15-288-21339
NCBI accession no.   NP_002195.1
UniProt accession no.   P26006
Gene Information   human ... ITGA3(3675)

Description

Immunogen

Immunogen Sequence: GI # 4504747, sequence 1015-1051

Recombinant integrin α 3 isoform a

Application

Anti-ITGA3 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Integrin α-3 is a protein encoded by the ITGA3 gene in humans and is a member of the integrin family of cell adhesion receptors. It is a transmembrane integrin receptor subunit for various laminin isoforms that mediates signals between the cells and their microenvironment. ITGA3 plays an important role in the maintenance of tissue integrity. It may function as a receptor for fibronectin, laminin, and collagen. ITGA3 plays a central role in the interplay of cells, morphogens and ECM and is required for proper nephrogenesis. It acts as a potential marker protein for cells undergoing enhanced Epithelial-mesenchymal transition (EMT) and for cancer cells with aggressive phenotypes.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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