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GW21353 Sigma-Aldrich

Anti-ITGAX antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-CD11c, Anti-Integrin α X

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Properties

Related Categories A to L, Alphabetical Index, Antibodies, IQ-IZ, IgY Antibodies,
conjugate   unconjugated
clone   polyclonal
biological source   chicken
application(s)   western blot: suitable
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
mfr. no.   Genway, 15-288-21353
NCBI accession no.   NP_000878.1
UniProt accession no.   P20702
Gene Information   human ... ITGAX(3687)

Description

General description

ITGAX (integrin, αX), also called CD11c, belongs to the integrin superfamily of glycoproteins. It is expressed on monocytes, inflammatory macrophages, dendritic cells, and neutrophils.

Immunogen

Immunogen Sequence: GI # 4504765, sequence 287-339

Recombinant integrin α X

Application

Anti-ITGAX antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Biochem/physiol Actions

The expression of Integrin, αX (complement component 3 receptor 4 subunit) (ITGAX) on monocytes helps in establishing a CMML (chronic myelomonocytic leukemia) diagnosis. Polycystic ovary syndrome (PCOS) is associated with an increase in CD11c expression. Its expression is rare in mantle cell lymphoma (MCL) and may aid in differentiation of CD5+ B-cell neoplasms.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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