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GW21980B Sigma-Aldrich

Anti-CARD14 (ab2) antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-CARD-containing MAGUK protein 2, Anti-Caspase recruitment domain-containing protein 14

  •  NACRES NA.41

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Properties

Related Categories A to L, Alphabetical Index, Antibodies, CAM-CB, IgY Antibodies,
conjugate   unconjugated
clone   polyclonal
biological source   chicken
application(s)   western blot: suitable
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
mfr. no.   Genway, 15-288-21980B
NCBI accession no.   NP_438170.1
UniProt accession no.   Q9BXL6
Gene Information   human ... CARD14(79092)

Description

General description

The gene CARD14 (caspase recruitment domain family member 14) encodes a member of the MAGUK (membrane-associated guanylate kinase) family of proteins. These proteins are scaffold proteins that participate in the assembly of multiprotein complexes at certain sites on the plasma membrane. The encoded protein contains an N-terminal CARD domain, a central coiled-coil domain, and a tripartite domain comprising of a PDZ (PSD-95, Dlg1, ZO-1) domain, an Src (Sarcoma) homology 3 domain, and a GUK (Guanylate kinase) domain at the C-terminus. The gene is mapped to human chromosome 17q25. It is mainly expressed in the basal and suprabasal layers of healthy skin epidermis.

Immunogen

Immunogen Sequence: GI # 16507955, sequence 221-330

Recombinant caspase recruitment domain protein 14 isoform 2

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

The gene CARD14 (caspase recruitment domain family member 14) encodes a nuclear factor that contains a CARD domain involved in binding to the CARD domain of BCL10 (B cell leukemia 10), a protein involved in the activation of NF-κB through the IKK complex, and positive regulation of apoptosis. Mutations in this gene are associated with familial pityriasis rubra pilaris, a papulosquamous disorder phenotypically related to psoriasis. It also activates p38 and JNK MAP (c-Jun N-terminal kinase mitogen-activated protein) kinase pathways via association with paracaspase-1 (PCASP-1), also referred to as MALT1, which can serve as a therapeutic target in psoriasis.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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