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GW22346 Sigma-Aldrich

Anti-BCAS2 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

  •  NACRES NA.41

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Properties

Related Categories A to L, Alphabetical Index, Antibodies, Antibodies for Epigenetics and Nuclear Signaling, Antibodies to RNA Binding Proteins,
conjugate   unconjugated
clone   polyclonal
biological source   chicken
application(s)   western blot: suitable
species reactivity   human, mouse, rat
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
mfr. no.   Genway, 15-288-22346
NCBI accession no.   NP_005863.1
UniProt accession no.   O75934
Gene Information   human ... BCAS2(10286)

Description

Immunogen

Immunogen Sequence: GI # 5031653, sequence 1-225

Recombinant breast carcinoma amplified sequence 2

Application

Anti-BCAS2 antibody produced in chicken is suitable western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Biochem/physiol Actions

Pre-mRNA-splicing factor SPF27 is a protein encoded by the BCAS2 gene in humans and is mapped to chromosome 1p13.3-21 region. It codes for a nuclear protein. BCAS2 is a novel gene up-regulated by amplification in human breast cancer cell lines. It acts as a transcriptional coactivator of estrogen receptor. It directly interacts with p53 to reduce p53 transcriptional activity and consistently decreases p53 protein in the absence of DNA damage. BCAS2 is a small nuclear protein (26kDa) and a novel negative regulator of p53. It is a potential molecular target for cancer therapy.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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