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GW22348F Sigma-Aldrich

Anti-LXN antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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Properties

Related Categories A to L, Alphabetical Index, Antibodies, IgY Antibodies, LRR-LZ,
conjugate   unconjugated
clone   polyclonal
biological source   chicken
application(s)   indirect ELISA: suitable
  western blot: suitable
species reactivity   mouse, human, rat
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
mfr. no.   Genway, 15-288-22348F
NCBI accession no.   NP_064554.1
UniProt accession no.   Q9BS40
Gene Information   human ... LXN(56925)

Description

General description

LXN (latexin) is the human homologue of endogenous inhibitor of carboxypeptidase A found in rat. It was initially recognized as a neural marker in developing mammalian brain, of the lateral neocortex. This protein is composed of 222 amino acids. An α-helix links two subdomains that comprise the protein. It has high structural homology to TIG1 (tazarotene-induced gene 1).

Immunogen

Immunogen Sequence: GI # 9910396, sequence 1-222

Recombinant latexin protein

Application

Anti-LXN antibody produced in chicken is suitable for indirect ELISA and western blotting.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Biochem/physiol Actions

Latexin (LXN) is a negative regulator of hematopoietic stem cell and may exert its tumor-suppressive function by altering the stem cell-like properties of melanoma cells. Its expression is reduced in human gastric cancers compared with their normal control tissues. LXN expression may have involvement in tumor suppression. It may have clinical efficacy in the treatment of malignancies.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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