• USA Home
  • GW22444 - Anti-Importin α2 subunit antibody produced in chicken

GW22444 Sigma-Aldrich

Anti-Importin α2 subunit antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

  •  NACRES NA.41



Related Categories A to L, Alphabetical Index, Antibodies, Antibodies for Epigenetics and Nuclear Signaling, Antibodies for Gene Regulation,
conjugate   unconjugated
clone   polyclonal
biological source   chicken
application(s)   western blot: suitable
species reactivity   human, rat, mouse
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
mfr. no.   Genway, 15-288-22444
NCBI accession no.   NP_002257.1
UniProt accession no.   P52292
Gene Information   human ... KPNA2(3838)


General description

Importin α2, also called KPNA2 (karyopherin α2), is an adaptor protein, which belongs to a family of nucleocytoplasmic transport proteins called karyopherin α (KPNA). This family contains around seven members, and KPNA2 is expressed in epidermal keratinocytes and undifferentiated embryonic cells.


Immunogen Sequence: GI # 4504897, sequence 1-529

Recombinant karyopherin α 2


Anti-Importin a2 subunit antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Importin subunit α-2 interacts with proteins associated with mRNA processing, ribonucleoprotein complex biogenesis, chromatin modification and transcription. KPNA2 expression is induced in tumor cells and in various proliferative disorders of the skin such as psoriasis, Bowen′s disease, actinic keratosis, squamous cell carcinoma, Paget′s disease, Merkel cell carcinoma, and mycosis fungoides. KPNA2 may act as an important promoter of ribosomal RNA and protein synthesis in tumor cells. Overexpression of KPNA2 is linked to poor prognosis in a variety of malignancies. KPNA2 functions as an adaptor by transporting several proteins to the nucleus. It might be a useful prognostic marker and an effective therapeutic target for gastric cancer (GC).

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy


Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

Related Content

Antibody Explorer | Buy Primary Antibodies & Secondary Antibodies

Primary, Secondary and Recombinant Monoclonal Antibodies Providing highly cited primary and secondary antibodies, we have you covered for your ELISA, western blot, immunohistochemistry or other assay...
Keywords: Alzheimer Disease, Cancer, Chromatin immunoprecipitation, Diagnostic, Enzyme-linked immunosorbent assay, Flow cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Neuroscience, Western blot

Peer-Reviewed Papers


Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?