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GW22661 Sigma-Aldrich

Anti-DNMT3A2 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

  •  NACRES NA.41

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Properties

Related Categories A to L, Alphabetical Index, Antibodies, Antibodies for Epigenetics and Nuclear Signaling, Antibodies to Epigenetic Regulators,
conjugate   unconjugated
clone   polyclonal
biological source   chicken
application(s)   western blot: suitable
species reactivity   human, mouse, rat
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
mfr. no.   Genway, 15-288-22661
NCBI accession no.   NP_783328.1
UniProt accession no.   Q59HC6
Gene Information   human ... DNMT3A(1788)

Description

General description

Chicken polyclonal anti-DNMT3A2 antibody reacts with human, rat, and mouse DNA (cytosine-5-)-methyltransferase 3 α 2 methyltransferases.

DNA (cytosine-5-)-methyltransferase 3 α (DNMT3A2) is involved in the epigenetic modification of genes involved in processes that regulate embryonic development, imprinting, and X-chromosome inactivation. For instance DNMT3A promotes the down regulation of Oct-3/4 to prevent reprogramming during early cell differentiation from the pluripotent state. Dysfunctional DNMT3A have been associated with incidence of acute myeloid leukemia (AML).

Immunogen

Immunogen Sequence: GI # 28559069, sequence 1-300

Recombinant DNA cytosine methyltransferase 3 α isoform a

Application

Chicken polyclonal anti-DNMT3A2 antibody is used to tag DNA (cytosine-5-)-methyltransferase 3 α 2 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of DNA (cytosine-5-)-methyltransferase 3 α 2 in post-translational (epigenetic) gene regulation involving the processes of embryonic development, imprinting, and X-chromosome inactivation.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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