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H0266 Sigma-Aldrich

Hemoglobin A2, Ferrous Stabilized human

lyophilized powder



Related Categories Application Index, Biochemicals and Reagents, Enzymes, Inhibitors, and Substrates, Hemoglobin, Plasma & Blood Proteins,
Quality Level   200
biological source   human
assay   97-100% (agarose gel electrophoresis)
form   lyophilized powder
application(s)   immunofluorescence: suitable
suitability   suitable for electrophoresis and chromatography standard (has not been tested for functional equivalence against native preparations (unlyophilized ferrous hemoglobins).)
storage temp.   −20°C
Gene Information   human ... HBA2(3040)


General description

Hemoglobin A2 (HBA2) is mapped to human chromosome 16p13.3. HBA2 is a minor hemoglobin component and comprises of two α and δ chains.

Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.


Hemoglobin A2 was used in the determination of fetal hemoglobin by time-resolved immunofluorometric assay.

Hemoglobin A2, Ferrous Stabilized human has been used as a reference in reversed-phase high-performance liquid chromatography for quantifying δ-globin elution profile. It has also been used as calibrator in isotope dilution mass spectrometry (IDMS) measurements.

Biochem/physiol Actions

Elevated levels of Hemoglobin A2 (HBA2) is observed in patients with β-thalassemia trait.


Package size indicates the amount of hemoglobin as determined by the procedure of Drabkin, D.L., J. Biol. Chem., 164, 703 (1946).


When reconstituted with buffer, gives >90% ferrous hemoglobin.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


Cellular Derived Blood Proteins and Enzymes

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