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H0417 Sigma-Aldrich

Heparin Cofactor II from human plasma

aqueous glycerol solution, ≥90% (SDS-PAGE)

Synonym: HCF2, HCII, SERPIND1

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Protease Inhibitor Specificity Index,
Quality Level   200
biological source   human plasma
assay   ≥90% (SDS-PAGE)
form   aqueous glycerol solution
mol wt   ~66 kDa
  ~66 kDa
NCBI accession no.   NP_000176
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... SERPIND1(3053)

Description

Biochem/physiol Actions

Heparin cofactor II (HCII), a member of the serpin superfamily, is a serine protease inhibitor that rapidly inactivates thrombin in the presence of dermatan sulfate, heparan sulfate, or heparin. In addition to its role in coagulation regulation, HCII may also participate in inflammation, atherosclerosis, and wound repair. For example, leukocyte-mediated degradation of HCII releases peptides that are chemotactic for neutrophils and monocytes which may promote acute inflammation and wound repair. It has also been reported that HCII and dermatan sulfate levels are elevated in pregnancy, suggesting that HCII may be protective against thrombosis during pregnancy.

Serine protease that inhibits thrombin, α-chymotrypsin, neutrophil cathepsin G, and Streptomyces griseus protease B.

Unit Definition

HCII is tested for activity using a Thrombin inhibition assay. One unit will inhibit one NIH unit of Thrombin.

Physical form

50% aqueous glycerol solution (vol/vol)

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
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