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  • H0652 - Anti-Hepatocyte Growth Factor antibody produced in goat

H0652 Sigma-Aldrich

Anti-Hepatocyte Growth Factor antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym: Anti-HGF



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies for Pancreatic Stem Cells,
conjugate   unconjugated
clone   polyclonal
biological source   goat
application(s)   neutralization: suitable
  neutralization: suitable
  western blot: suitable
species reactivity   human
form   lyophilized powder
storage temp.   −20°C
antibody form   IgG fraction of antiserum
Quality Level   100
antibody product type   primary antibodies
UniProt accession no.   P14210
Gene Information   human ... HGF(3082)


General description

Hepatocyte Growth Factor (HGF) is a multifunctional, heparin-binding factor that stimulates the proliferation of liver cells. The cellular effects of HGF are mediated by its receptor, c-Met, that leads to significant activation of ERK, Src/FAK, STAT3 and PI3K signaling. Cells of mesenchymal origin express HGF that stimulates the c-Met expression via an autocrine loop. Various functions of the HGF/c-Met signaling include proliferation, cell survival, motility and adhesion and tissue regeneration. Apart from liver, HGF also mediates regeneration of kidney, lung and gastro-intestines. It is also important for maintaining the insulin production and prevents hypoglycemia, self-repair of cartilage, muscle and skin and hematopoiesis. The HGF/c-Met signaling is reported as a promising therapeutic target in prevention of angiogenesis in cancer and maintaining synaptic plasticity in Alzheimer’s disease
Monoclonal Anti-Hepatocyte Growth Factor recognizes human HGF.


recombinant human hepatocyte growth factor.


Anti-Hepatocyte Growth Factor antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml is recommended. The antibody is suitable for neutralization reactions. A concentration of 500ng/ml of anti-HGF has been used to neutralize HGF in the conditioned medium of NIH3TS cells. Anti-HGF has been used at a working concentration of 20μg/ml for immunohistochemistry of section of cervical lesions.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Preparation Note

Purified by Protein G.

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy


Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers


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