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H0786 Sigma-Aldrich

Heregulin-β, EGF Domain human

≥80% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution

Synonym: HRG-β

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Description

General description

Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.

Biochem/physiol Actions

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

Physical form

Solution in phosphate buffered saline containing 30% glycerol.

Analysis Note

Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.

The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Cell Culture Guide
Protocols & Articles

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