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H3160 Sigma-Aldrich

Hydrocortisone

meets USP testing specifications

Synonym: 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M

  • CAS Number 50-23-7

  • Empirical Formula (Hill Notation) C21H30O5

  • Molecular Weight 362.46

  •  Beilstein/REAXYS Number 1354819

  •  EC Number 200-020-1

  •  MDL number MFCD00011654

  •  PubChem Substance ID 24895560

  •  NACRES NA.21

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Properties

Related Categories Analytical/Chromatography, Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Core Bioreagents,
Quality Level   300
biological source   plant (wild yam)
Agency/Method   meets USP testing specifications
assay   97.0-102.0% dry basis
form   powder
potency   0.004-0.005 μg/mL
mp   211-214 °C (lit.)
solubility   water: soluble 0.28 g/L at 25 °C
Featured Industry   Pharmaceutical (small molecule)
storage temp.   room temp
SMILES string   [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
InChI   1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChI key   JYGXADMDTFJGBT-VWUMJDOOSA-N
Gene Information   human ... ABCB1(5243), CYP3A4(1576), NR3C1(2908), SERPINA6(866)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126)
rat ... Ar(24208), Nr3c1(24413)

Description

Packaging

5, 10, 25 g in poly bottle

Biochem/physiol Actions

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
GM8925000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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