EMAIL THIS PAGE TO A FRIEND
H4628 Sigma-Aldrich

DL-Homocysteine

≥95% (titration)

Synonym: 2-Amino-4-mercaptobutyric acid

  • CAS Number 454-29-5

  • Linear Formula HSCH2CH2CH(NH2)COOH

  • Molecular Weight 135.18

  •  Beilstein/REAXYS Number 1721683

  •  EC Number 207-222-9

  •  MDL number MFCD00004898

  •  eCl@ss 42021308

  •  PubChem Substance ID 24895646

  •  NACRES NA.26

Purchase

Properties

Related Categories Amino Acid, Amino acids, Cancer Research, Cell Biology, Chemical Biology,
Quality Level   100
assay   ≥95% (titration)
form   powder
application(s)   cell analysis: suitable
  peptide synthesis: suitable
mp   232-233 °C (lit.)
solubility   H2O: soluble
storage temp.   −20°C
SMILES string   NC(CCS)C(O)=O
InChI   1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)
InChI key   FFFHZYDWPBMWHY-UHFFFAOYSA-N

Description

Application

DL-Homocysteine has been used to induce hyperhomocysteinemia in Sprague–Dawley rats. It has also been used to study the effects of hyperhomocysteinemia on atherosclerosis in apolipoprotein E-deficient mice.

Packaging

1, 5, 25 g in poly bottle

10 mg in autosample vial

Biochem/physiol Actions

Homocysteine is a sulfhydryl-containing amino acid, synthesized from methionine. It is a non-essential, non-proteinogenic amino acid. It is an important determinant of the methylation cycle and is present in the plasma in four forms. An abnormally high level of homocysteine leads to hyperhomocysteinemia and also promotes atherosclerosis.

Increased plasma homocysteine is a risk factor for coronary heart disease and carcinogenesis; may be a marker for tumor cell growth.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. H4628.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
MT0175000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number
Protocols & Articles

Articles

Characteristic Metabolites for Inborn Errors of Amino Acid Metabolism

Inborn errors of metabolism are caused by changes in specific enzymatic reactions and hundreds of different such alterations, which affect about 1 of every 5000 newborns, have been characterized. The...
Keywords: Indicators, Metabolism, Metabolites

Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?