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H5777 Sigma-Aldrich

(±)-Huperzine A

synthetic, ≥98% (TLC)

Synonym: (±)-Selagine

  • CAS Number 120786-18-7

  • Empirical Formula (Hill Notation) C15H18N2O

  • Molecular Weight 242.32

  •  MDL number MFCD00171439

  •  PubChem Substance ID 24895708

  •  NACRES NA.77

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Properties

Related Categories A to C, Acetylcholinesterase, Alkaloid, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
Quality Level   100
biological source   synthetic
assay   ≥98% (TLC)
form   powder
solubility   methanol: 10 mg/mL, clear, colorless
storage temp.   2-8°C
SMILES string   C\C=C1/C2CC3=C(C=CC(=O)N3)C1(N)CC(C)=C2
InChI   1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+
InChI key   ZRJBHWIHUMBLCN-QDEBKDIKSA-N
Gene Information   human ... BCHE(590)
rat ... Ache(83817)

Description

General description

Huperzine A is an alkaloid derived from Chinese club moss Huperzia serrata.

Application

(±)-Huperzine A has been used in anti-acetylcholinesterase bioautographic assay.

Biochem/physiol Actions

Huperzine A is an effective acetylcholinesterase inhibitor and can cross the blood-brain barrier. Huperzine A is known to prevent cognitive defects, glutamate-induced nerve cell death.It is recognized for its use in the treatment of Alzheimer′s disease and organophosphate poisoning.

Chem/Phys Resistance

Acetylcholinesterase inhibitor.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Target organs 
Respiratory system
RIDADR 
UN 1544PSN1 6.1 / PGII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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