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H6166 Sigma-Aldrich

Interferon α 2B human

IFN-α 2B, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

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Properties

Related Categories Cell Culture, Growth Factors and Cytokines, HumanKine Growth Factors and Cytokines, Interferons, Reagents and Supplements More...
biological source   human
recombinant   expressed in HEK 293 cells
assay   ≥95% (SDS-PAGE)
form   lyophilized powder
potency   ≤0.16 ng/mL ED50
quality   endotoxin tested
mol wt   dimer 16 kDa (glycosylated)
packaging   poly bottle of 10 μg (in poly bottle)
mfr. no.   HumanZyme
impurities   ≤1EU/mg
suitability   suitable for cell culture
UniProt accession no.   P01563
storage temp.   −20°C
Gene Information   human ... IFNA2(3440)

Description

Analysis Note

The specific activity was determined by the dose-dependent proliferation of WISH (heteroploid human amnion cell line) in presence of VSV ( vesicular stomatitis virus).

Packaging

10 μg in poly bottle

Preparation Note

HumanKine IFN-α 2B is a glycosylated monomer expressed in HEK 293 cells with an apparent molecular mass of 16 kDa. Production in human 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Biochem/physiol Actions

Interferon α 2B (IFN-α 2B) belongs to the type I interferon protein family. It is produced by many cell types in response to viral infection. IFN-α 2B has antiproliferative and antitumor activities, as well as induction of apoptosis and the inflammatory response. It enhances the expression of MHC proteins by increasing the presentation of antigen peptides and activates cytotoxic T-cells.

Legal Information

HumanKine is a registered trademark of HumanZyme Inc.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

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Peer-Reviewed Papers
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References

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