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H6649 Sigma-Aldrich

Herbimycin A from Streptomyces hygroscopicus

≥95% (HPLC), powder

  • CAS Number 70563-58-5

  • Empirical Formula (Hill Notation) C30H42N2O9

  • Molecular Weight 574.66

  •  Beilstein/REAXYS Number 4834067

  •  MDL number MFCD00151702

  •  PubChem Substance ID 24895756

  •  NACRES NA.77

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application, Antibiotics by Mechanism of Action,
Quality Level   200
biological source   Streptomyces hygroscopicus
assay   ≥95% (HPLC)
form   powder
color   yellow
solubility   DMSO: 7.5 mg/mL (DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.)
Mode of action   enzyme | inhibits
antibiotic activity spectrum   viruses
storage temp.   −20°C
SMILES string   CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O
InChI   1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
InChI key   MCAHMSDENAOJFZ-BVXDHVRPSA-N

Description

General description

Chemical structure: benzenoid

Biochem/physiol Actions

An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.

Caution

Hygroscopic and photosensitive

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
LX8930000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

The Role of Inflammation in Neurodegeneration

It is well established that the brain can sense and react to peripheral insults through the rapid induction of fever and other neuroendocrine changes in response to events such as infection and tissu...
Scott Hauser, Technology Transfer Specialist, Sigma® Life Science
Biofiles, Vol. 8, No. 19
Keywords: Adhesion, Central Nervous System, Diseases, Gene expression, Inflammation, Neurodegenerative Diseases, Reductions

Peer-Reviewed Papers
15

References

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