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H6891 Sigma-Aldrich

7β-Hydroxycholesterol

≥95%

Synonym: 5-Cholestene-3β,7β-diol

  • CAS Number 566-27-8

  • Empirical Formula (Hill Notation) C27H46O2

  • Molecular Weight 402.65

  •  MDL number MFCD00058406

  •  PubChem Substance ID 24895774

  •  NACRES NA.77

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Properties

Related Categories Anti-Proliferative Agents, Antitumor Agents, Biochemicals and Reagents, Cancer Research, Cell Biology,
InChI Key   OYXZMSRRJOYLLO-UHFFFAOYSA-N
Quality Level   200
assay   ≥95%

Description

Application

7β-hydroxycholesterol was used to study oxysterol-induced apoptosis in human endothelial cells.

Packaging

1, 5 mg in glass bottle

10 mg in poly bottle

Biochem/physiol Actions

7β-Hydroxycholesterol is an oxysterol, the enzymatic or non-enzymatic product of cholesterol oxidation. Oxysterols are cytotoxic and induce death in monocytes, smooth muscle cells and endothelial cells. The mechanism of apoptosis induced by oxysterols may involve caspases or DNA fragmentation. Increased levels of 7β-Hydroxycholesterol correlates with increased risk of cardiovascular diseases including atherosclerosis.

Preparation Note

7β-Hydroxycholesterol yields clear, colorless to faint yellow solution in ethanol, with or without heating.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

BACSMLS Online Plate Map

BACSMLS compounds are conveniently provided at 5µg per well, enough for multiple injections. These are high purity (>95%) compounds supplied in an economical, ready to use format. Compounds are arran...
Keywords: Metabolites

Peer-Reviewed Papers
15

References

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