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H7660 Sigma-Aldrich

Heregulin-β1 (EGF Domain) human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym: HRG-β1

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Description

Analysis Note

The biological activity is measured by its ability to stimulate the proliferation of human MCF-7 cells grown under serum-free conditions.

Biochem/physiol Actions

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


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Cell Culture Guide
Protocols & Articles

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Peer-Reviewed Papers
15

References

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