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H7750 Sigma-Aldrich

DL-Histidine

≥99% (TLC)

Synonym: (±)-2-Amino-3-(4-imidazolyl)propionic acid

  • CAS Number 4998-57-6

  • Empirical Formula (Hill Notation) C6H9N3O2

  • Molecular Weight 155.15

  •  Beilstein/REAXYS Number 7800

  •  EC Number 225-660-9

  •  MDL number MFCD00005208

  •  eCl@ss 32160406

  •  PubChem Substance ID 24895803

  •  NACRES NA.26

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Properties

Related Categories Amino Acids, Amino Acids & Derivatives, Biochemicals and Reagents, Chemical Biology, Chemical Synthesis,
Quality Level   200
assay   ≥99% (TLC)
form   powder
application(s)   ligand binding assay: suitable
  peptide synthesis: suitable
mp   273 °C (dec.) (lit.)
solubility   0.5 M HCl: soluble
SMILES string   NC(Cc1c[nH]cn1)C(O)=O
InChI   1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)
InChI key   HNDVDQJCIGZPNO-UHFFFAOYSA-N

Description

Application

DL-Histidine has been used to study the fouling behaviour of polyethersulfone ultrafiltration membranes made with different PVP (polyvinylpyrrolidone).

DL-Histidine is the mixed isomer of D- and L-histidine. DL-Histidine may be used to evaluate the efficiency of amino acid chiral ligand exchange media and systems and in running buffers for capillary electrophoresis.

Packaging

25, 100 g in poly bottle

Biochem/physiol Actions

L-Histidine is involved in the one-carbon unit metabolism. It is associated with protein methylation. L-Histidine is a part of hemoglobin structure and function. L-Histidine is a component of dipeptides with antioxidative property. Histidine serves as a precursor for the formation of histamine, which is associated with allergic responses. Urocanic acid, an immune response modulator in skin is also biosynthesised from histidine.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

HPLC Analysis of Histidine Enantiomers on Astec® CHIROBIOTIC® T (23 °C)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Histidine Enantiomers on Astec® CHIROBIOTIC® T (23 °C)
Keywords: Chromatography, High performance liquid chromatography

Related Content

Amino Acids Reference Charts

Amino acids are the compounds or building blocks that make up peptides and proteins. Each amino acid is structured from an amino group and a carboxyl group bound to a tetrahedral carbon. This carbon ...
Keywords: Building blocks, Gene expression, Mass spectrometry

Peer-Reviewed Papers
15

References

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