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H8041 Sigma-Aldrich

Interleukin-23 human

IL-23, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

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Properties

Related Categories Cell Culture, Growth Factors and Cytokines, HumanKine Growth Factors and Cytokines, Interleukin-23, Interleukins (IL),
biological source   human
recombinant   expressed in HEK 293 cells
assay   ≥95% (SDS-PAGE)
form   lyophilized powder
potency   ≤40 ng/mL ED50
quality   endotoxin tested
mol wt   dimer 55 kDa (glycosylated)
packaging   pkg of 5X10 μg
  pkg of 10 μg
  pkg of 5 μg
mfr. no.   HumanZyme
impurities   ≤1EU/mg
suitability   suitable for cell culture
storage temp.   −20°C
Gene Information   human ... IL23A(51561)

Description

General description

HumanKine interleukin-23 (IL-23) is expressed as a heterodimeric 55 kDa cytokine composed of two glycosylated and disulfide linked subunits (p40 cystine linked to p19). Production in human HEK 293 cells offers authentic glycosylation. Cytokines produced in Sf9 or Sf21 cells have post-translational modifications, which are not human-like.

Interleukin-23 (IL-23) is a pro-inflammatory cytokine. It is mostly synthesized by activated dendritic cells and macrophages. It is a 20.7kDa protein with 189 amino acids. IL-23 is mostly expressed on activated/memory T cells and natural killer (NK) cells. This gene is located on human chromosome 12q13.3.

Biochem/physiol Actions

Interleukin-23 (IL-23) plays a major role in cutaneous immune-mediated inflammatory diseases like psoriasis, allergic contact dermatitis and atopic dermatitis. It is involved in cellular immunity, driving the expansion, stabilization and survival of Th17 cells.

Analysis Note

The specific activity was determined by the dose-dependent secretion of h-IFN-γ or IL-8 from human PBMC.

Legal Information

HumanKine is a registered trademark of HumanZyme Inc.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Certificate of Origin

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Peer-Reviewed Papers
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References

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