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H8384 Sigma-Aldrich

(Hydroxypropyl)methyl cellulose

viscosity 40-60 cP, 2 % in H2O(20 °C)(lit.)



Related Categories Biochemicals and Reagents, Carbohydrates, Oligosaccharide More...
Quality Level   200
form   powder
mol wt   ~22 kDa
viscosity   40-60 cP, 2 % in H2O(20 °C)(lit.)
storage temp.   room temp



Thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.


25, 100, 250 g in poly bottle

Features and Benefits

Dissolves in water, undergoes reversible gelation upon heating, non-ionic, does not complex with ionic species and is surface active and enzyme resistant. Solutions are pseudoplastic.


Normally contains some iron particles.

Preparation Note

This product is soluble in water (10 mg/ml). However, it is very important to thoroughly disperse the particles in water with agitation before they will dissolve. Otherwise, they will lump and form a gelatinous membrane around the internal particles, preventing them from wetting completely. There are four dispersion techniques commonly used to prepare solutions of hydroxypropylmethylcellulose: dispersion in hot water, dry blending, dispersion in non-solvent medium, and dispersion of surface-treated powders. (The last method is only for surface-treated powders).

Dispersion in hot water:
1. Heat approximately 1/3 the required volume of water to at least 90 oC.
2. Add the powder to the heated water with stirring or agitation.
3. Agitate the mixture until the particles are thoroughly wetted and evenly dispersed.
4. Add the remainder of the water (cold water) to lower the temperature of the dispersion. As the product cools, it will reach a temperature at which it becomes water soluble. It will then begin to hydrate and dissolve, increasing the viscosity of the solution.
5. Continue agitation for at least 30 minutes after the proper temperature is reached for solubility. The solution is now ready to use.

Dry blending:
1. Combine powder with other dry ingredients. The suggested ratio of dry powder to hydroxypropylmethylcellulose is 7:1 to 3:1.
2. Thoroughly blend the dry ingredients.
3. Add the dry mixture to water with agitation.
4. Agitate until the product has completed hydrated and the solution is consistently smooth. The solution is now ready for further processing/use.

Dispersion in non-solvent medium:
1. Hydroxypropylmethylcellulose may be dispersed in non-solvent media such as vegetable oil, polyethylene glycol, glycerin, corn syrup, and concentrated salt solutions. A ratio of 5-8 parts non-solvent to 1 part hydroxypropylmethylcellulose is recommended to obtain a liquid slurry.
2. Agitate the mixture until the particles are evenly dispersed.
3. This dispersion may be added to cold water or cold water may be added to the dispersion.
4. Continue mixing until the powder is completely hydrated and the solution is smooth. Additional ingredients may now be added to the formulation.

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers


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