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H8502 Sigma-Aldrich

Dopamine hydrochloride

Synonym: 2-(3,4-Dihydroxyphenyl)ethylamine hydrochloride, 3,4-Dihydroxyphenethylamine hydrochloride, 3-Hydroxytyramine hydrochloride, 4-(2-Aminoethyl)-1,2-benzenediol hydrochloride

  • CAS Number 62-31-7

  • Linear Formula (HO)2C6H3CH2CH2NH2·HCl

  • Molecular Weight 189.64

  •  Beilstein/REAXYS Number 3656720

  •  EC Number 200-527-8

  •  MDL number MFCD00012898

  •  PubChem Substance ID 24277897

  •  NACRES NA.77



Related Categories Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Catecholamine,
Quality Level   200
form   powder
color   light tan
mp   248-250 °C (lit.)
solubility   alcohol: 20 mg/mL
  H2O: soluble
storage temp.   2-8°C
SMILES string   Cl[H].NCCc1ccc(O)c(O)c1
InChI   1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H
Gene Information   human ... ADRB1(153)


General description

Dopamine (DA) works as neurotransmitter in the central nervous system. It is a catecholamine made from the amino acid L-tyrosine. It also works as a hormone in vesicles of the adrenal medulla, thereby controlling heart beat rate and blood pressure. Absence of DA-containing neurons is associated with parkinson’s disease.


• Dopamine hydrochloride has been used to study dopamine-mediated transient modulation of the physiological responses in whiteleg shrimp, Litopenaeus vannamei.
• It has been used to study dopamine-mediated changes in immunity susceptibility to Lactococcus garvieae in the freshwater giant prawn, Macrobrachium rosenbergii.
• It has been used to study the molecular link between dopamine-induced oxidative stress and mHtt (mutant Huntingtin) toxicity in relation to the activation of the autophagy pathway in an ‘in vitro’ model of parkinsonian Huntington′s Disease.


5, 10, 25, 100 g in poly bottle

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.


Light sensitive

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. H8502.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
UN 3077 9 / PGIII
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


Discover Bioactive Small Molecules for Neuroscience

The nervous system, comprised of the brain and spinal cord (central nervous system, or CNS) and network of nerves that connects the CNS to the rest of the body (peripheral nervous system, or PNS) is ...
Keywords: Bioactive small molecules, Central Nervous System, Diseases, Metabolism, Neurodegenerative Diseases, Neuroscience, Neurotransmission, Neurotransmitters

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Stationary Phase Selectivity in Aqueous Normal-Phase/Hydrophilic Interaction Chromatographic (ANP/HILIC) Separations

The term aqueous normal-phase/hydrophilic interaction chromatography (ANP/HILIC) refers to liquid chromatography performed using highly organic (> 70%) mobile phases and relatively polar stationary p...
Carmen T. Santasania and David S. Bell
Reporter US Volume 24.5
Keywords: Applications, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Methods, Neurotransmitters, Normal-phase chromatography, Reversed-phase chromatography, Separation

Peer-Reviewed Papers


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95199 Fluorescent Dopamine Neurotransmitter Ligand, labeled with Dansyl, suitable for fluorescence, ≥98% (HPLC)

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