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H9291 Sigma-Aldrich

Hemopexin from human plasma

≥95% (SDS-PAGE), lyophilized powder

Synonym: HPX, HX, Hpxn, beta-1B-glycoprotein

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood, Immune System Regulation, Proteins of Inflammation More...
Quality Level   100
biological source   human plasma
assay   ≥95% (SDS-PAGE)
form   lyophilized powder
mol wt   ~57 kDa
application(s)   microbiological culture: suitable
NCBI accession no.   NP_000604
storage temp.   −20°C
Gene Information   human ... HPX(3263)

Description

General description

Hemopexin (HPX) is produced by cells of the central nervous system. It is a 60 kDa serum glycoprotein.

Application

Hemopexin from human plasma has been used S. aureus surface colonization assay. It has also been used to stimulate mixed lymphocyte cells to determine the biomarkers in acute rejection.

Packaging

500 μg in poly bottle

Biochem/physiol Actions

Hemopexin is an acute-phase protein that plays a major protective role against oxidative stress through its heme-scavenging activities. Hemopexin binds heme with high affinity and is critical for recycling the iron bound to heme molecules and for protecting against heme-induced cellular damage. Free heme, when released or lost from proteins like hemoglobin, can catalyze the formation of reactive oxygen species. Heme is lipophilic and interchelates into lipid membranes and participate in the formation of highly-toxic hydroxyl radicals. Hemopexin may also protect against the heme-mediated oxidation of LDL cholesterol.

Hemopexin may also serve an anti-inflammatory role via the negative regulation of IL-6 and TNF-α secretion by activated macrophages.

Physical form

Lyophilized powder containing sodium phosphate, NaCl, and KCl, pH 7.4

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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