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H9523 Sigma-Aldrich

Serotonin hydrochloride


Synonym: 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, 5-Hydroxytryptamine hydrochloride

  • CAS Number 153-98-0

  • Empirical Formula (Hill Notation) C10H12N2O · HCl

  • Molecular Weight 212.68

  •  Beilstein/REAXYS Number 3570963

  •  MDL number MFCD00012686

  •  PubChem Substance ID 24278124

  •  NACRES NA.77



Related Categories Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
Quality Level   200
assay   ≥98%
form   powder
color   white to off-white
mp   149-154 °C (lit.)
solubility   H2O: 17 mg/mL
  0.1 M HCl: 22 mg/mL
  ethanol: 5.3 mg/mL
storage temp.   2-8°C
SMILES string   Cl[H].NCCc1c[nH]c2ccc(O)cc12
InChI   1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H
Gene Information   human ... HTR3A(3359)



1 g in glass bottle

100, 250 mg in glass bottle

25 mg in poly bottle

Biochem/physiol Actions


Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Solutions should be freshly prepared.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Target organs 
Respiratory system
Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Can I store solutions of Product H9523, Serotonin hydrochloride?
Solutions of this product are unstable.We recommend preparing this solution fresh for each application.
Is Product H9523, Serotonin hydrochloride, the neurotransmitter serotonin?
This product is the neurotransmitter serotonin.Other synonyms for this product are 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, and 5-Hydroxytryptamine hydrochloride.
What are the storage conditions for Product H9523, Serotonin hydrochloride?
This product is a powder and should be refrigerated at 2-8°C. We do not recommend storing solutions of this product.
Has Product H9523, Serotonin hydrochloride, been cell culture tested?
No. We do not test this product for cell culture suitability.
What is the purity of Product H9523, Serotonin hydrochloride?
This product must be at least 98% pure according to our specifications.The purity for individual lots can be found on the certificate of analysis.
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Protocols & Articles


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MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

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