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HPA018305 Sigma

Anti-KCNQ4 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym: Anti-KQT-like 4, Anti-Potassium channel subunit alpha KvLQT4, Anti-Potassium voltage-gated channel subfamily KQT member 4, Anti-Voltage-gated potassium channel subunit Kv74



Related Categories Alphabetical Index, Antibodies, K, K-KH, Prestige Antibodies,
species reactivity   human
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous glycerol solution
grade   Prestige Antibodies® Powered by Atlas Antibodies
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... KCNQ4(9132)
biological source   rabbit
conjugate   unconjugated



Potassium voltage-gated channel subfamily KQT member 4 recombinant protein epitope signature tag (PrEST)

General description

The gene potassium voltage-gated channel subfamily KQT member-4 (KCNQ4) is mapped to human chromosome 1p34. It belongs to KCNQ family of K+ channels and forms heteromeric complexes with KCNQ3. KCNQ4 transcripts are detected in heart, brain, and skeletal muscle. KCNQ4 is also strongly expressed in the inner ear and the central auditory pathway. In the inner ear, KCNQ4 is particularly present in the basal membrane of sensory outer hair cells. KCNQ4 has six transmembrane domains, a pore forming region and two intracellular termini. The protein is localized in the plasma membrane.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide


All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collecation of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

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Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC


Corresponding Antigen APREST73231.

Biochem/physiol Actions

HSP40 (Heat shock protein 40)-HSP70-HOP (HSP70-HSP90 organizing protein)-HSP90 chaperone pathway is responsible for maintaining potassium voltage-gated channel KQT member-4 (KCNQ4) homeostasis in the cell. Mutations in KCNQ4 are associated with autosomal dominant hearing loss. In addition, KCNQ4 plays protective role in the pulmonary circulation and prevents hypoxia-induced pulmonary circulation. KCNQ4 is important for myogenesis. Cannabinoid receptor of type-1 represses myoblast differentiation by reducing KCNQ4 levels.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
WGK Germany  1
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy


Prestige Antibody® Immunofluorescence Procedure

Prestige Antibodies® have been used for subcellular localization studies by immunocytochemistry (ICC) - immunofluorescence (IF) using the protocol described below. In addition to the primary antibodi...
Keywords: Immunocytochemistry, Immunofluorescence, Immunostaining, Sample preparations

Prestige Antibody® Immunohistochemistry Procedure

Prestige Antibodies® developed for immunohistochemistry based expression profiling are recommended to be used according to the standard IHC staining protocol described below.
Keywords: Buffers, Dehydration reaction, Gene expression, Hydration reaction, Immunohistochemistry, Immunostaining, Tissue microarrays

Prestige Antibody® Protein Immunoblotting Procedure

Prestige Antibodies® recommended for Western Blot are recommended to be used according to the standard WB protocol described below. Western blot standard protocol optimized for
Keywords: Catalytic combustion detector, Electrophoresis, Gene expression, Sample preparations, Western blot

Prestige Antigens™-Blocking Protocol

Prestige Antigens and the corresponding Prestige Antibodies are recommended to be used according to the standard blocking protocol described below.
Keywords: Immunocytochemistry, Immunohistochemistry, Immunostaining, Titrations, Western blot

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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