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I0281 Sigma-Aldrich

Interleukin-4/Fc Chimera (non-lytic) from mouse

>98% (SDS-PAGE), recombinant, expressed in CHO cells, buffered aqueous solution

Synonym: IL-4:Fc (non-lytic)

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Properties

Related Categories Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines & Growth Factors,
Quality Level   200
biological source   mouse
recombinant   expressed in CHO cells
assay   >98% (SDS-PAGE)
form   buffered aqueous solution
mol wt   98 kDa
packaging   pkg of 10 μg
impurities   endotoxin, tested
UniProt accession no.   P07750
shipped in   wet ice
storage temp.   −20°C
Gene Information   mouse ... Il4(16189)

Description

Biochem/physiol Actions

In mice, absence of IL-4 (interleukin-4) causes anxiety-like behavior. It is secreted by Th2 (T helper) cells and works as a pro-inflammatory cytokine. It plays an important role in immune response and allergic diseases. It is also associated with schistosoma mansoni pulmonary hypertension.

Possesses the biological functions of the IL-4 moiety and a prolonged circulating half-life determined by the Fc domain.

Other Notes

Dimeric fusion protein consisting of mouse IL-4 fused to mutant mouse Fcγ2a Fc.

Physical form

Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4.

Safety & Documentation

Safety Information

WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

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Peer-Reviewed Papers
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References

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