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  • I0779 - Interleukin-2 Soluble Receptor α human

I0779 Sigma-Aldrich

Interleukin-2 Soluble Receptor α human

>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: CD25, IL-2 sRα, Tac antigen



Biochem/physiol Actions

Interleukin-2 (IL-2), a cytokine, enhances Th (T helper) cell differentiation and effector responses. In addition, it helps in immune tolerance. IL-2 binds to the high affinity receptor, formed of IL2RA (interleukin 2 receptor subunit α), IL2RB (interleukin 2 receptor subunit β) and γ-chain. Polymorphism in IL2RA is associated with multiple sclerosis. Null mutation in IL2RA results in immune dysregulation.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin.

Analysis Note

The bioactivity is measured by its ability to inhibit the IL-2-dependent proliferation of a human megakaryocytic leukemic cell line, M07e.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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