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I0908 Sigma-Aldrich

Insulin human

meets USP testing specifications

  • CAS Number 11061-68-0

  • Empirical Formula (Hill Notation) C257H383N65O77S6

  • Molecular Weight 5807.57

  •  EC Number 234-279-7

  •  MDL number MFCD00131380

  •  NACRES NA.21

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Properties

Related Categories Analytical/Chromatography, Biochemicals and Reagents, Insulin and related, Pharmacopoeia, Pharmacopoeia A-Z,
Quality Level   200
biological source   human
recombinant   expressed in Saccharomyces cerevisiae
Agency/Method   meets USP testing specifications
assay   ≥27.5 units/mg dry basis
form   solid
potency   ≥27.5 units/mg
application(s)   cell culture | mammalian: suitable
Featured Industry   Pharmaceutical (small molecule)
storage temp.   −20°C
InChI key   PBGKTOXHQIOBKM-FHFVDXKLSA-N
Gene Information   human ... INS(3630)

Description

Packaging

50, 250 mg in poly bottle

Biochem/physiol Actions

Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
nwg
RTECS 
NM8900250
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What is the solublity and solution stability for Product I0908, Insulin?
As Product I0908 - Insulin human meets USP specifications, we only report out the USP testing results. In the USP method, Insulin is dissolved in 0.01N HCl. Insulin is readily soluble (10-20 mg/ml) in weak acids.For Product I2643, recombinant human insulin, we indicate the following storage conditions. A stock solution can be stored frozen at -20°C in single-use aliquots. Freeze-thaw cycles should be avoided. Alternatively, it can be stored for up to 12 months at 2-8°C, if it is sterile filtered through a low protein binding membrane or if it contains a suitable bacteriostat, such as 0.1% thimerosal or sodium azide.
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Protocols & Articles

Articles

HPLC Analysis of Insulin (Species Variants) on Ascentis® Express Phenyl-Hexyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Insulin (Species Variants) on Ascentis® Express Phenyl-Hexyl
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Insulin (Species Variants) on BIOshell™ A160 Peptide C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Insulin (Species Variants) on BIOshell™ A160 Peptide C18
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Insulin (Species Variants) on Discovery® BIO Wide Pore C5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Insulin (Species Variants) on Discovery® BIO Wide Pore C5
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Insulin on SRT®-C SEC-300

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Insulin on SRT®-C SEC-300
Keywords: Chromatography, High performance liquid chromatography, Size-exclusion chromatography

Peer-Reviewed Papers
15

References

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