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I1020 Sigma-Aldrich

Interleukin-4 from mouse

IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym: Interleukin-4 human, mIL-4

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Properties

Related Categories Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines & Growth Factors,
biological source   mouse
recombinant   expressed in E. coli
assay   ≥98% (SDS-PAGE)
form   lyophilized powder
potency   0.1-2.0 ng/mL ED50/EC50
quality   endotoxin tested
mol wt   ~13.5 kDa
packaging   pkg of 5 μg
impurities   <0.1 EU/μg
suitability   suitable for cell culture
UniProt accession no.   P07750
storage temp.   −20°C
Gene Information   mouse ... Il4(16189)

Description

Biochem/physiol Actions

Interleukin-4 (IL-4) is a lymphokine with profound effects on the growth and differentiation of immunologically competent cells. IL-4 is also known as B cell stimulatory factor-1 (BSF-1), T cell growth factor-2 (TCGF-2) and mast-cell growth factor-2 (MCGF-2). Inhibits VEGF-induced and FGF-Basic-induced angiogenesis. IL-4 is a complex glycoprotein released by a subset of activated T cells. Treatment of IL-4 with specific glycosidases yields an active polypeptide. Human and mouse IL-4 share 50% amino acid sequence homology, but their biological actions are species-specific.

Physical form

Lyophilized, 0.2 μm filtered, with no additives.

Analysis Note

The proliferative activity is tested in culture using mouse HT-2 cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Pipette Controller from Brand

Cell Culture Guide
Protocols & Articles

Articles

Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages...
Jennifer Fries
BioFiles 2009, 4.5, 16.
Keywords: Anti-inflammatory agents, Antitumor agents, Cancer, Cell proliferation, Gene expression, Growth factors, Transcription

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Cell culture has become one of the most fundamental techniques for modeling biological systems, and is of increasing importance in the biotechnology and pharmaceutical sectors as well as an essential...
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