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I122 Sigma-Aldrich

ICI 204,448 hydrochloride

solid

Synonym: (±)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride, R,S-[3-[1-[[(3,4-Dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl] phenoxy]-acetic acid hydrochloride

  • CAS Number 121264-04-8

  • Empirical Formula (Hill Notation) C23H26Cl2N2O4 · HCl

  • Molecular Weight 501.83

  •  MDL number MFCD00153814

  •  PubChem Substance ID 24278040

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
form   solid
color   white
solubility   45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 12 mg/mL
  dilute sodium carbonate: 4 mg/mL
  H2O: 4.5 mg/mL
SMILES string   Cl[H].CN(C(CN1CCCC1)c2cccc(OCC(O)=O)c2)C(=O)Cc3ccc(Cl)c(Cl)c3
InChI   1S/C23H26Cl2N2O4.ClH/c1-26(22(28)12-16-7-8-19(24)20(25)11-16)21(14-27-9-2-3-10-27)17-5-4-6-18(13-17)31-15-23(29)30;/h4-8,11,13,21H,2-3,9-10,12,14-15H2,1H3,(H,29,30);1H
InChI key   FNDGLVOYAQNQPE-UHFFFAOYSA-N
Gene Information   human ... OPRK1(4986)

Description

Packaging

25 mg in poly bottle

5 mg in glass bottle

Biochem/physiol Actions

κ opioid receptor agonist that does not cross the blood-brain barrier.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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