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I1507 Sigma-Aldrich

Insulin human

≥95% (HPLC), semisynthetic, powder

  • CAS Number 11061-68-0

  • Empirical Formula (Hill Notation) C257H383N65O77S6

  • Molecular Weight 5807.57

  •  EC Number 234-279-7

  •  MDL number MFCD00131380

  •  NACRES NA.83

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Description

General description

Insulin gene is located on human chromosome 11p15.5.

Application

Insulin human has been used as a component of adipocyte differentiation media.

Biochem/physiol Actions

Insulin is important to maintain normal blood sugar levels. Insulin deficiency is associated with diabetes mellitus.

Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.

Preparation Note

Derived from porcine insulin

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
nwg
RTECS 
NM8900250

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Insulin Signaling and Energy Homeostasis

Glucose metabolism is regulated by the opposing actions of insulin and glucagon. Insulin is released from pancreatic ß cells in response to high blood glucose levels and regulates glucose metabolism ...
Linda Stephenson, Ph.D.
Biofiles v6 n4, 2011
Keywords: Apoptosis, Biological processes, Carboxylations, Catalog, Diabetes, Gene expression, Gluconeogenesis, Glycolysis, Hormones, Metabolism, Metabolites, Transcription, Transduction, Type

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Reversed-Phase HPLC Analysis of Insulin Variants and Analogs by UV and Mass Spectral Detection

Insulin is an approximately 6000 Da peptide hormone used to regulate the glucose concentration in blood. There are several different forms of insulin that are both natural and recombinant; the recomb...
Cory Muraco, Stacy Shollenberger, and Hillel Brandes
MilliporeSigma, Bellefonte, PA USA
Keywords: Chromatography, High performance liquid chromatography, Hormones, Mass spectrometry, Pharmaceutical, Phase transitions, Reversed-phase chromatography, Separation

Peer-Reviewed Papers
15

References

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I9278 Insulin solution human, sterile-filtered, BioXtra, suitable for cell culture

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