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I1521 Sigma-Aldrich

DES (1-6) IGF II

lyophilized powder, recombinant, expressed in E. coli, suitable for cell culture

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Properties

Related Categories Cell Culture, Growth Factor Analogs, Growth Factors and Cytokines, Reagents and Supplements
biological source   human
recombinant   expressed in E. coli
assay   ≥95% (HPLC)
form   lyophilized powder
potency   ≤100 ng/mL ED50
mol wt   6,765 Da
packaging   pkg of 20 μg
storage condition   avoid repeated freeze/thaw cycles
application(s)   cell culture | mammalian: suitable
impurities   endotoxin, tested
color   white
UniProt accession no.   P01344
storage temp.   2-8°C
Gene Information   human ... IGF2(3481)

Description

General description

DES (1-6) IGF-II is a 61 amino acid analog of human insulin-like growth factor II, lacking the first six N-terminal amimo acids. DES (1-6) IGF-II exhibits reduced affinity for IGF binding proteins (IGFBPs), which are known to inhibit the actions of IGF′s.

Application

Used for studies of IGF-II function in cell culture applications. Use in combination with IGF-I, insulin and other forms of IGF-II to study receptor functions and cell signaling.

Other Notes

Recombinant analog of insulin-like growth factor II.

Preparation Note

Prepared from 0.1 M acetic acid.

Synthesized recombinantly in E. coli using a patented fusion protein expression system, DES (1-6) IGF-II is then purified by liquid chromatography. DES (1-6) IGF-II has been developed as an inexpensive, high quality potent analog of IGF-II for use as a growth factor supplement in cell culture. DES (1-6) IGF-II is supplied as a powder, lyophilized from 0.1 M acetic acid. Molecular weight is 6,765 daltons.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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