I1521 Sigma-Aldrich

DES (1-6) IGF II

lyophilized powder, recombinant, expressed in E. coli, suitable for cell culture



Related Categories Cell Culture, Growth Factor Analogs, Growth Factors and Cytokines, Reagents and Supplements
biological source   human
recombinant   expressed in E. coli
assay   ≥95% (HPLC)
form   lyophilized powder
potency   ≤100 ng/mL ED50
mol wt   6,765 Da
packaging   pkg of 20 μg
storage condition   avoid repeated freeze/thaw cycles
application(s)   cell culture | mammalian: suitable
impurities   endotoxin, tested
color   white
UniProt accession no.   P01344
storage temp.   2-8°C
Gene Information   human ... IGF2(3481)


General description

DES (1-6) IGF-II is a 61 amino acid analog of human insulin-like growth factor II, lacking the first six N-terminal amimo acids. DES (1-6) IGF-II exhibits reduced affinity for IGF binding proteins (IGFBPs), which are known to inhibit the actions of IGF′s.


Used for studies of IGF-II function in cell culture applications. Use in combination with IGF-I, insulin and other forms of IGF-II to study receptor functions and cell signaling.

Other Notes

Recombinant analog of insulin-like growth factor II.

Preparation Note

Prepared from 0.1 M acetic acid.

Synthesized recombinantly in E. coli using a patented fusion protein expression system, DES (1-6) IGF-II is then purified by liquid chromatography. DES (1-6) IGF-II has been developed as an inexpensive, high quality potent analog of IGF-II for use as a growth factor supplement in cell culture. DES (1-6) IGF-II is supplied as a powder, lyophilized from 0.1 M acetic acid. Molecular weight is 6,765 daltons.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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