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I152 Sigma-Aldrich

I-309 human

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Chemokines, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones,
biological source   human
recombinant   expressed in E. coli
assay   >97% (SDS-PAGE)
form   lyophilized powder
potency   30-60 ng/mL ED50
mol wt   8.5  kDa
storage condition   avoid repeated freeze/thaw cycles
application(s)   cell culture | mammalian: suitable
impurities   endotoxin, tested
UniProt accession no.   P22362
storage temp.   −20°C
Gene Information   human ... CCL1(6346)

Description

Biochem/physiol Actions

I-309, a chemoattractant for monocytes but not neutrophils, is an approximately 8.5 kDa polypeptide of 73 amino acids. Human I-309 is thought to be a homolog of the mouse TCA3, and shows 42% amino acid homology to mouse TCA3.

I-309, a glycoprotein, is a chemoattractant for monocytes. It is secreted by monocytes, activated macrophages and T lymphocytes. Presence of I-309 in lymph node lymphatic sinuses controls metastases into the lymph nodes. It suppresses CCR8 (C-C motif chemokine receptor 8)-induced HIV (human immunodeficiency virus) infection and also participates in angiogenesis. I-309 is also referred to as CCL1 (C-C motif chemokine ligand 1).

Physical form

Lyophilized from 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin.

Analysis Note

Bioactivity measured by ability of I-309 to chemoattract hCCR8 transfected BaF/3 cells.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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