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I1771 Sigma-Aldrich

Interleukin-13 human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, cell culture tested

Synonym: IL-13

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Properties

Related Categories Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines & Growth Factors,
biological source   human
recombinant   expressed in E. coli
assay   ≥97% (SDS-PAGE)
form   lyophilized powder
potency   <10.000 ng/mL ED50
mol wt   12 kDa
packaging   pkg of 10 μg
impurities   endotoxin, tested
color   white
suitability   cell culture tested
UniProt accession no.   P35225
storage temp.   −20°C
Gene Information   human ... IL13(3596)

Description

Biochem/physiol Actions

IL-13 is known to be overexpressed in glioblastoma tumors and cell lines. Elevated IL-13 expression is also observed in parasitic infections. It stimulates fibrosis in many infectious diseases, and acts as a profibrogenic factor.

Interleukin-13 is a pleiotropic cytokine produced by activated Th2 cells in the mouse and human. IL-13 is secreted mainly as an unglycosylated protein of 132 amino acids with a molecular weight of 10,000 daltons. A 4.3kb DNA fragment of the mouse IL-13 gene was sequenced and occurs as a single copy mapping a chromosome 11. In the human, a 4.6 kb DNA segment of the IL-13 gene occurs as a single copy and maps to chromosome 5. IL-13 induces B cell proliferation and also induces IgE switching. The proliferative activity of human and mouse IL-13 products are tested in culture using the human erythroleukemic cell line TF-1.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 250 μg BSA.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Pipette Controller from Brand

Cell Culture Guide
Protocols & Articles

Articles

Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages...
Jennifer Fries
BioFiles 2009, 4.5, 16.
Keywords: Anti-inflammatory agents, Antitumor agents, Cancer, Cell proliferation, Gene expression, Growth factors, Transcription

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Cell Culture Troubleshooting Guide

Cell culture has become one of the most fundamental techniques for modeling biological systems, and is of increasing importance in the biotechnology and pharmaceutical sectors as well as an essential...
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Peer-Reviewed Papers
15

References

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