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  • I1783 - Anti-phospho-Insulin Receptor (IR) (pTyr972) antibody produced in rabbit

I1783 Sigma-Aldrich

Anti-phospho-Insulin Receptor (IR) (pTyr972) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies for Pancreatic Stem Cells,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
species reactivity   mouse, human
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −70°C
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
UniProt accession no.   P14616
Gene Information   human ... INSRR(3645)
mouse ... Insr(16337)


General description

The biological effects of insulin are mediated by insulin receptor (IR) and IGF-1 receptor. Insulin receptor consists of two α and two β subunits, each subunit has a tyrosine kinase domain. Signaling by IR is important in cell proliferation and metabolism of glucose. Insulin receptor activates the PI3K/Akt and the FKHR pathway, thereby regulates metabolism and insulin-dependent gene expression. Tyrosine 972 is an autophosphorylation site that is present in the juxtamembrane domain. Phosphorylation at Tyr972 is required for interaction of IR with its intracellular substrates and increases the stability of IR and substrate complexes. Overexpression of IR has been observed in breast cancer tissue and is implicated in proliferation of breast cancer cells, hyperinsulinemia and insulin resistance. IR can also bind IGF-I and IGF-II with decreased affinity
Anti-phospho-IR (pTyr972) recognizes human and mouse IR phosphorylated on tyrosine 972. It may cross react with IGF-1R.


This antibody may also have cross-reactivity with phosphosphorylated insulin-like growth factor-1 receptor (IGF-1R).


phosphopeptide derived from the region of human insulin receptor (IR) that contains tyrosine 972.

Physical form

Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 50% glycerol with 1 mg/ml of bovine serum albumin and 0.05% sodium azide.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles


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