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I2764 Sigma-Aldrich

ML-7

powder

Synonym: 1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride

  • CAS Number 110448-33-4

  • Empirical Formula (Hill Notation) C15H17IN2O2S · HCl

  • Molecular Weight 452.74

  •  MDL number MFCD00065524

  •  PubChem Substance ID 24278490

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   200
assay   ≥98% (TLC)
form   powder
color   white
solubility   ethanol: water (1:1): 10 mg/mL, clear, colorless to faintly yellow
storage temp.   −20°C
SMILES string   Cl.Ic1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3
InChI   1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
InChI key   KDDALCDYHZIZMH-UHFFFAOYSA-N
Gene Information   human ... MYLK(4638), MYLK2(85366)

Description

Application

ML-7 has been used as a myosin light chain kinase (MLCK) inhibitor in various experiments.

Packaging

5 mg in glass bottle

Biochem/physiol Actions

Selective myosin light chain kinase inhibitor.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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