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  • I2768 - Monoclonal Anti-IgD antibody produced in mouse

I2768 Sigma-Aldrich

Monoclonal Anti-IgD antibody produced in mouse

clone HJ9, purified immunoglobulin, buffered aqueous solution

Synonym: Monoclonal Anti-Human IgD



Related Categories Alphabetical Index, Analytical Cytology, Antibodies, Antibodies for Cell Biology, Antibodies for Immune Cell Signaling and Blood,
conjugate   unconjugated
clone   HJ9, monoclonal
biological source   mouse
application(s)   flow cytometry: 5 μL using 1 × 106 cells
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   2-8°C
antibody form   purified immunoglobulin
isotype   IgG1
antibody product type   secondary antibodies
UniProt accession no.   P01880
Gene Information   human ... IGHD(3495)


General description

The gene IgD (immunoglobulin heavy constant δ) encodes the major antigen receptor isotype that is expressed on the surface of B lymphocytes along with IgM. There are two forms of IgD, the membrane-bound form and the form secreted in to the serum. The serum IgD constitutes only 0.2% of all immunoglobulins. The δ heavy chain of IgD contains a four-domain structure comprising of a variable region (VH), and three constant region domains named Cδ1, Cδ2, Cδ3. The C region also contains an unusual hinge region of approximately 64 residues. The N-terminal end is referred to as GalN-rich segment. The C-terminal end is rich in glutamic acid and lysine and is referred to as high-charge segment.


Recognizes the delta chain of human IgD and is not reactive with heavy chains from human IgG1, IgG2, IgG3, IgG4, IgM, IgA, or kappa and lambda light chains.


human IgD

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

IgD (immunoglobulin heavy constant δ) is a class of immunoglobulin that may function in facilitating antibody secretion and participating in early antibody secretion. The serum IgD level may vary from undetectable to 140mg/L. Increased levels of serum IgD has been observed in clinical conditions, such as IgD myeloma, Hodgkin′s disease, sarcoidosis and tuberculosis, aspergillosis, ataxia-telangiectasia, AIDS, hyperimmunoglobulinemia D and periodic fever (HIDS) syndrome. IgD induces inflammatory cytokines, such as TNF (tumor necrosis factor)-α, IL-1β (interleukin 1β), IL-6 and may regulate several interactions and processes related to inflammation and immune response. It may also participate in the pathogenesis of HIDS.

Other Notes

IgD is expressed on peripheral B cells and is used as a pan-B cell marker.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Protocols & Articles


Antibody Basics

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