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  • I2907 - Monoclonal Anti-Interleukin-7 Receptor α antibody produced in mouse

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I2907 Sigma-Aldrich

Monoclonal Anti-Interleukin-7 Receptor α antibody produced in mouse

clone 40131, purified immunoglobulin, lyophilized powder

Synonym: Anti-CD127, Anti-IL-7 Rα

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Description

General description

Interleukin-7 (IL-7) is a stromal-cell derived cytokine that is important in the development of adaptive immunity and maintenance of T cells and B cells. IL-7 is produced by bone marrow cells, liver and intestinal epithelia cells, dendritic cells, smooth muscle cells, fibroblasts macrophages and keratinocytes. The effect of IL-7 is mediated by IL-7 receptor consisting of an α chain and a γ chain and by the subsequent activation of JAK/STAT, PI3K and Src kinases. Important roles of IL-7 include proliferation of lymphoid progenitors, survival and homeostasis of naïve and memory T cells
Monoclonal Anti-Interleukin-7 receptor α recognizes recombinant human IL-7Rα (approximately 55-65 kDa). In immunoblotting, the antibody shows approximately 5% cross-reactivity with recombinant human IL-10R, recombinant human IL-2R, recombinant human IL-5R α, and recombinant human IL-6R.

Immunogen

purified recombinant human IL-7 receptor α extracellular domain, expressed in insect Sf 21 cells.

Application

Anti-Interleukin-7 receptor α antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For ELISA the working concentration recommended is 0.5-1.0 μg/ml.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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I8409 Anti-Interleukin-7 Receptor α/CD127 antibody produced in goat, affinity isolated antibody, lyophilized powder
I7284 Anti-Interleukin-7 Receptor α/CD127 antibody produced in goat, affinity isolated antibody, lyophilized powder

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