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I3265 Sigma-Aldrich

Interferon-γ human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), lyophilized powder, cell culture tested

Synonym: IFN-γ

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Properties

Related Categories Bioactives/Supplements, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors,
biological source   human
recombinant   expressed in E. coli
assay   ≥98% (SDS-PAGE)
form   lyophilized powder
mol wt   ~17 kDa
packaging   pkg of 0.1 mg
impurities   ≤1 EU/μg endotoxin
color   white
solubility   water: soluble 1.000 mL, clear, colorless
suitability   cell culture tested
UniProt accession no.   P01579
storage temp.   −20°C
Gene Information   human ... IFNG(3458)

Description

Application

Interferon-γ human has been used:
• to study the effect of interferon-γ on cultured trophoblasts in absence and presence of fibronectin
• to analyse factors which participate in the production of antibody microarrays on glass support
• for ELISA (enzyme-linked immunosorbent assay) method to understand the effect of interferon-γ in human gingival fibroblasts in presence of bacterial challenge

Biochem/physiol Actions

IFNG (interferon-γ) is a type-2 interferon which is produced by Th (T helper cells)-1 lymphocytes, CD8 cytotoxic lymphocytes, natural killer (NK) cells, and natural killer T (NKT) cells. It plays an important role in innate and adaptive immune responses, and helps in defense against bacterial infections, dimorphic yeast and some viral infections. High expression of IFNG is common in many autoimmune diseases, such as systemic lupus erythematosis, Sjögren syndrome, inflammatory bowel disease and multiple sclerosis.

Physical form

Lyophilized from phosphate buffered saline.

Analysis Note

The biological activity is measured by a viral resistance assay.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Cell Culture Guide
Protocols & Articles

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Peer-Reviewed Papers
15

References

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